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Shanen M. Sherrer

Associate Professor of Biochemistry

Shanen M. Sherrer

Biography

Dr. Shanen M. Sherrer is a versatile scientist, educator, and administrator. Her broad training in the chemical, biological, and biomedical sciences included biochemical research across various organisms – primarily in archaea, yeast, and human model systems. Dr. Sherrer’s past research experiences focused on determining mutagenic profiles and pre-steady state kinetic characteristics of error-prone DNA replication and studying the molecular mechanism of the human DNA mismatch repair pathway. Notably, she worked as a Howard Hughes Medical Institute (HHMI) Research Associate (2011-2013) in the HHMI laboratory of Nobel Laureate Dr. Paul L. Modrich before completing a 3-year American Cancer Society Postdoctoral Fellowship (2014-2017) in the same laboratory.  

After earning tenure as a faculty member at St. Mary’s College of Maryland (SMCM), Dr. Sherrer completed a 2-year American Association for the Advancement of Science (AAAS) Science and Technology Policy Fellowship (2023-2025) at the National Institutes of Health (NIH). During this time at the NIH, she worked for the National Cancer Institute (NCI) in the Division of Cancer Prevention, and she completed a work detail in the NCI Division of Cancer Biology. Dr. Sherrer’s work as an NIH scientist-administrator earned her 3 NCI awards, including an NCI Director’s Award. Dr. Sherrer’s undergraduate student-centered research program at SMCM studies the impact of environmental pollutants on DNA-protein interactions using both classical and novel techniques such as chromatography, thermal scanning, molecular cloning, gel electrophoresis, and metal-indicating fluorophores. Her rigorous courses and research training practices help prepare students to enter the scientific workforce, graduate schools, and health professional programs.

Areas of Research Specialization

  • DNA damage and repair
  • Enzymology
  • Protein folding
  • Toxicology

Areas of Teaching Specialization

  • Biochemistry
  • General Chemistry
  • Marine Environmental Toxicology

Education

  • Ph.D. in Biochemistry at The Ohio State University, 2011
  • B.S. in Biochemistry at Miami University, 2005

Awards

  • AAAS Science & Technology Policy Fellowship, 2023-2025

    A policy fellowship with placement at the National Institutes of Health (NIH) National Cancer Institute's (NCI) Division of Cancer Prevention and a short work detail at the NCI Division of Cancer Biology.

  • NCI Division of Cancer Prevention Group Award, 2024 (1st Award)
  • NCI Division of Cancer Prevention Group Award, 2024 (2nd Award)
  • NCI Director's Award, 2025

    For work completed in 2024.

Spotlight

  • St. Mary’s College Assistant Professors Malisch and Sherrer Offer Starting Points for Ensuring Gender Equity in Academia that are Amplified by the COVID-19 Pandemic

    Summary of work by Drs. Jessica Malisch, Shanen M. Sherrer and others in the recently published Proceedings of the National Academy of Sciences (PNAS) of the United States of America peer-reviewed article, “In the Wake of COVID-19, Academia Needs New Solutions to Ensure Gender Equity”.

  • St. Mary’s College Chemistry and Biochemistry Professors Among Authors of ACS Symposium Series Book

    To address the national need of professional skills training for chemists and biochemists, Shanen Sherrer and six other faculty members of the Department of Chemistry and Biochemistry authored seven chapters for a recently released American Chemical Society (ACS) Symposium Series book, “Integrating Professional Skills into Undergraduate Chemistry Curricula.” This published book was developed from a symposium planned for the 2020 National Meeting of the American Chemical Society in Philadelphia that would address each of the chapters as a talk; however, it was canceled due to the COVID-19 pandemic. The value of the content was such that the ACS continued with the book project, and the corresponding symposium ran virtually at the 2021 Spring ACS Annual Meeting.

  • Assistant Professor Sherrer Publishes Study on the Harmful Impacts of Cadmium in Human DNA Mismatch Repair with Nobel Laureate

    Shanen M. Sherrer, assistant professor of biochemistry, is the lead author on a new research article with Nobel Laureate Paul Modrich in the Proceedings of the National Academy of Sciences. Their work shows the impact of cadmium exposure on human DNA mismatch repair (MMR). In particular, they discovered human MMR protein MutLα is inhibited by cadmium, which can lead to increased genetic mutations and cancer.

  • An Unexpected Path

    Dr. Shanen M. Sherrer discusses her unexpected path into cancer research.