Assistant Professor Chaudhury Published in FEBS Letters

Submitted by Aileen Bailey on February 02, 2021 - 1:33 pm
February 02, 2021
By Aileen Bailey

Indrajit Chaudhury, visiting assistant professor of biology, has recently been published in FEBS Letters titled, “Fanconi anemia and mTOR pathways functionally interact during stalled replication fork recovery.”

In this article, Chaudhury and colleagues demonstrate that the non-Fanconi anemia (FA) protein mechanistic target of rapamycin (mTOR) interacts and cooperates with the FA protein FANCD2 during replication stress to provide cellular stability and to prevent nucleolytic degradation. Chaudhury and colleagues recommend that their findings have translational applicability as novel strategies can be designed to utilize mTOR inhibitors and replication fork stalling agents to selectively inhibit certain biochemical pathways in cancer cells.